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Thiolated polymers or designated thiomers are mucoadhesive polymers which display thiol group bearing side chains. In brief, low molecular mass thiol group bearing compounds are covalently bound to a polymeric backbone. This backbone consists of well-established and safe polymers such as chitosan or poly(acrylic acid). It has been demonstrated in various studies, that thiomers exhibit mucoadhesive, permeation enhancing, controlled release as well as enzyme and efflux pump inhibitory properties. These features make the thiomer technology highly interesting for non-invasive delivery routes, including in first instance the oral but also the nasal, buccal and vaginal route. Thiomers can be directly compressed to tablets or given as solutions. Furthermore thiomer based micro- and nanoparticles have already been developed. Numerous original research and review articles as well as book contributions have been published in recent years: ==Review articles== * Bernkop-Schnürch A. Chitosan and its derivatives: potential excipients for peroral peptide delivery systems. Int J Pharm 2000;194(1):1-13. * Bernkop-Schnürch A. Thiomers: A new generation of mucoadhesive polymers. Adv Drug Deliv Rev 2004;57(11):1569-82. * Albrecht K. and Bernkop-Schnürch A. Thiomers: forms, functions and applications to nanomedicine. Nanomed. 2007 Feb;2(1):41-50. * Bernkop-Schnürch A., Krauland A.H., Leitner V.M., Palmberger T. Thiomers: potential excipients for non-invasive peptide delivery systems. Eur J Pharm Biopharm. 2004 Sep;58(2):253-63. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Thiomer」の詳細全文を読む スポンサード リンク
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