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Thioperamide : ウィキペディア英語版 | Thioperamide
Thioperamide is a potent HRH4 antagonist and selective HRH3 antagonist capable of crossing the blood–brain barrier. It was used by Jean-Charles Schwartz in his early experiments regarding the H3 receptor.〔Schwartz, Jean-Charles. The histamine H3 receptor: from discovery to clinical trials with pitolisant. ''BPJ'' 2011 May ()〕 Thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine, and enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine. == See also ==
* H3 receptor antagonist
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