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Words near each other
・ Thionyl chloride
・ Thionyl fluoride
・ Thionyl tetrafluoride
・ Thioperamide
・ Thiophene
・ Thiophene-2-carbonyl-CoA monooxygenase
・ Thiophenol
・ Thiophosgene
・ Thiophosphate
・ Thiophosphoric acid
・ Thiophosphoryl chloride
・ Thiophosphoryl fluoride
・ Thioploca
・ Thioploca araucae
・ Thioploca chileae
Thiopropamine
・ Thiopropazate
・ Thioproperazine
・ Thioproscaline
・ Thioptera
・ Thiopurine
・ Thiopurine methyltransferase
・ Thiopyran
・ Thiopyrylium
・ Thioredoxin
・ Thioredoxin domain
・ Thioredoxin fold
・ Thioredoxin reductase
・ Thiorhodospira sibirica
・ Thiorhodovibrio winogradskyi


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Thiopropamine : ウィキペディア英語版
Thiopropamine

Thiopropamine is a stimulant drug which is an analogue of amphetamine where the phenyl ring has been replaced by thiophene. It has similar stimulant effects to amphetamine but with around one third the potency. The N-methyl and thiophen-3-yl analogues are also known and are somewhat more potent, though still generally weaker than the corresponding amphetamines.
==Pharmacology==
Like amphetamine and most of its analogues, thiopropamine most likely is a norepinephrine-dopamine reuptake inhibitor and/or releasing agent.
Thiopropamine is likely to be metabolized into active 4-hydroxymethiopropamine and thiophene S-oxides. These are further deaminated by CYP2C in liver transforming them into inactive 1-(Thiophen-2-yl)-2-propan-2-one which is a phenylacetone derivative. Propan-2-amines are not metabolized by monoamine oxidases and most actually behave as competitive monoamine oxidase inhibitors.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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