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Tiamenidine
Tiamenidine (BAN, USAN, INN, also known as thiamenidine, Hoe 440) is a imidazoline compound that shares many of the pharmacological properties of clonidine. It acts as a cetrally-acting α1 and α1 adrenergic receptor antagonist (with IC50 4.85μM and 0.0091μM, respectively). In hypertensive volunteers, like clonidine, it significantly increased sinus node recovery time and lowered cardiac output. It was marketed (as tiamenidine hydrochloride) by Sanofi-Aventis〔(【引用サイトリンク】url=http://drugs-about.com/drugs-s/sundralen.html )〕 under the brand name Sundralen for the management of essential hypertension. ==Synthesis==
Reaction of thiourea 1 with methyl iodide gives the corresponding S-methyl analogue (2), followed by heating with ethylenediamine, completes the synthesis of tiamenidine (3).
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Tiamenidine」の詳細全文を読む
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