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Tivantinib : ウィキペディア英語版
Tivantinib

Tivantinib (ARQ197; by Arqule, Inc.) is an experimental anti-cancer drug. It is a bisindolylmaleimide that binds to the dephosphorylated MET kinase ''in vitro''. Tivantinib is being tested clinically as a highly selective MET inhibitor.〔(【引用サイトリンク】title=ArQule Announces Commencement of Phase 3 Clinical Trial with Tivantinib in Hepatocellular Carcinoma by Partner Kyowa Hakko Kirin in Japan - WSJ.com )〕 However, the mechanism of action of tivantinib is still unclear.
Tivantinib displays cytotoxic activity via molecular mechanisms that are independent from its ability to bind MET.
Possible applications include non-small-cell lung carcinoma, hepatocellular carcinoma, and oesophageal cancer.
==References==



抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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