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Tolazoline
Tolazoline is a non-selective competitive α-adrenergic receptor antagonist. It is a vasodilator that is used to treat spasms of peripheral blood vessels (as in acrocyanosis). It has also been used (in conjunction with Sodium nitroprusside) successfully as an antidote to reverse the severe peripheral vasoconstriction which can occur as a result of overdose with certain 5-HT2A agonist drugs such as 25I-NBOMe, DOB and Bromodragonfly (prolonged severe vasoconstriction can lead to gangrene if untreated).〔Bowen JS, Davis GB, Kearney TE, Bardin J. Diffuse vascular spasm associated with 4-bromo-2,5-dimethoxyamphetamine ingestion. ''Journal of the American Medical Association'' 1983 Mar 18;249(11):1477-9. PMID 6827726〕〔Thorlacius K, Borna C, Personne M. Bromo-dragon fly--life-threatening drug. Can cause tissue necrosis as demonstrated by the first described case. (Swedish) ''Lakartidningen''. 2008 Apr 16-22;105(16):1199-200. PMID 18522262〕 It is however most commonly used in veterinary medicine, to reverse xylazine-induced sedation.〔 Retrieved September 8, 2008 through Google Book Search.〕〔 Retrieved September 8, 2008 through Google Book Search.〕 ==References==
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