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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Tonofibril ： ウィキペディア英語版 Tonofibril Tonofibrils, discovered by Rudolf Heidenhain, and first described in detail by Louis-Antoine Ranvier, are cytoplasmic protein structures in epithelial tissues that converge at desmosomes and hemidesmosomes. Characterized by the fine fibrils in the epithelial cells(). Tonofilaments are also associated with desmosomes (macula adherens), anchoring them to the cytoskeleton. ==Composition== Tonofilaments are keratin intermediate filaments that make up tonofibrils in epithelial tissue. In epithelial cells, tonofilaments loop through desmosomes. Electron microscopy has advanced to now illustrate the Tonofilaments more clearly(). The protein filaggrin is believed to have an important role in holding them together as tonofibrils. This protein is known to interact with intermediate filaments, specifically keratins. It is synthesized as a giant Precursor protein, profilaggrin (>400 kDA in humans). When the filaggrin binds to keratin intermediate filaments, it causes aggregation in macrofibrils. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Tonofibril」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.