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Triazavirin
Triazavirin (TZV) is a broad-spectrum antiviral drug developed in Russia through a joint effort of Ural Federal University, Russian Academy of Sciences, Ural Center for Biopharma Technologies and Medsintez Pharmaceutical. It has an azoloazine base structure, which represents a new structural class of non-nucleoside antiviral drugs.〔Rusinov VL, Sapozhnikova IM, Ulomskii EN, Medvedeva NR, Egorov VV, Kiselev OI, Deeva EG, Vasin AV, Chupakhin ON. Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins. ''Chemistry of Heterocyclic Compounds'' 2015;51(3):275-280. doi 10.1007/s10593-015-1695-4〕 It was originally developed as a potential treatment for pandemic influenza strains such as H5N1, and most of the testing that has been done has focused on its anti-influenza activity.〔Loginova SIa, Borisevich SV, Maksimov VA, Bondarev VP, Kotovskaia SK, Rusinov VL, Charushin VN. Investigation of triazavirin antiviral activity against influenza A virus (H5N1) in cell culture. (Russian) ''Antibiotiki i Khimioterapiia''. 2007;52(11-12):18-20. PMID 19275052〕〔Karpenko I, Deev S, Kiselev O, Charushin V, Rusinov V, Ulomsky E, Deeva E, Yanvarev D, Ivanov A, Smirnova O, Kochetkov S, Chupakhin O, Kukhanova M. Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication. ''Antimicrobial Agents and Chemotherapy''. 2010 May;54(5):2017-22. doi: 10.1128/AAC.01186-09 PMID 20194696〕〔Kiselev OI, Deeva EG, Mel'nikova TI, Kozeletskaia KN, Kiselev AS, Rusinov VL, Charushin VN, Chupakhin ON. A new antiviral drug Triazavirin: results of phase II clinical trial. (Russian). ''Voprosy Virusologii''. 2012 Nov-Dec;57(6):9-12. PMID 23477247〕 However triazavirin has also been found to have antiviral activity against a number of other viruses including tick-borne encephalitis,〔Loginova SIa, Borisevich SV, Rusinov VL, Ulomskiĭ UN, Charushin VN, Chupakhin ON. Investigation of Triazavirin antiviral activity against tick-borne encephalitis pathogen in cell culture. (Russian). ''Antibiotiki i Khimioterapiia''. 2014;59(1-2):3-5. PMID 25051708〕 and is also being investigated for potential application against Lassa fever and Ebola virus disease.〔(【引用サイトリンク】url=http://english.pravda.ru/health/22-12-2014/129359-target_ebola-0/ )〕〔(【引用サイトリンク】url=http://yekaterinburgnews.com/daily-news/yekaterinburg-pharmacies-to-sell-domestic-antiviral-drug/11873/ )〕〔(【引用サイトリンク】title=Ebola crisis: Vaccine 'too late' for outbreak. BBC News, 17 October 2014 )〕〔(Kukil Bora. Russia Will Begin Testing Triazavirin, Used For Lassa Fever, And Other Drugs On Ebola: Health Ministry. International Business Times, 12 November 2014 )〕〔(Darya Kezina. New antiviral drug from Urals will help fight Ebola and other viruses. Russia Beyond the Headlines, 12 November 2014 )〕
==See also==
* BCX4430
* Brincidofovir
* Favipiravir
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