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Trimebutine
Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.〔Kaneto H, Takahashi M, Watanabe J. The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. ''Journal of Pharmacobiodynamics''. 1990 Jul;13(7):448-53. PMID 1963196〕 The maleic acid salt of trimebutine is marketed under the trademark of Debridat, Recutin, Polybutin,〔Ok Hwa Jhee, Yun Sik Lee, Leslie M. Shaw, Yong Cheol Jeon, Min Ho Lee, Seung Hoon Lee and Ju Seop Kang The Pharmacokinetic and bioequivalence evaluation of two formulations of 100 mg trimebutine maleate (Recutin and Polybutin) in healthy male volunteers using the LC–MS/MS method. ''Clinica Chimica Acta''. 2007 Jan;375(1-2):69-75. PMID 16854404〕 or Modulon for treatment of irritable bowel syndrome and other gastrointestinal disorders. The major product from drug metabolism of trimebutine in human beings is nortrimebutine,〔F.J. Roman, S. Lanet, J. Hamon, G. Brunelle, A. Maurin, P. Champeroux, S. Richard, N. Alessandri, and M. Gola Pharmacological Properties of Trimebutine and N-Monodesmethyltrimebutine. ''The Journal of Pharmacology and Experimental Therapeutics'' 1999;289:1391–1397. PMID 10336531〕 which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract. Both Trimebutine and its metabolite are commercially available.
==See also==
* Asimadoline
* Fedotozine
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