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Trogocytosis
Trogocytosis (; ''gnaw'') is a process whereby lymphocytes (B, T and NK cells) conjugated to antigen-presenting cells extract surface molecules from these cells and express them on their own surface.〔E. Joly and D. Hudrisier in Nature Immunology volume 4 page 815 (2003)〕 The molecular reorganization occurring at the interface between the lymphocyte and the antigen-presenting cell during conjugation is also called “immunological synapse”.
== Steps in the discovery of trogocytosis ==
First indication for the existence of this process dates back late 70s when several research groups reported on the presence of unexpected molecules such as Major Histocompatibility complex molecules (MHC) on T cells. The notion that membrane fragments, and not isolated molecules, could be captured by T cells on antigen-presenting cells was suggested by the capture of MHC molecules fused to the green fluorescent protein (GFP) in their intracellular portion.〔JF. Huang et al in Science volume 256 page 952 (1999)〕 The demonstration that membrane fragments were involved in this transfer process came when fluorescent probes incorporated in the plasma membrane of the antigen-presenting cell as well as non-MHC molecules were found to be captured by T cells together with the antigen.〔D. Patel et al in Journal of Immunology volume 163 page 5221 (1999)〕〔D. Hudrisier et al in Journal of Immunology volume 166 page 3645 (2001)〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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