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Trophogen
Trophogen, Inc. is a biotechnology company based in Rockville, Maryland.
Company was founded in 2001 with Series A funding from Toucan Capital,〔Breaking with academia a tough choice for scientists. The Daily Record, March 2002〕〔Local biotech pulls NIH license away from giant pharma. Washington Business Journal, March 2002〕 focusing on the development of human and bovine high affinity glycoprotein hormone and related growth factor superagonist analogs 〔(Effects of recombinant human thyroid-stimulating hormone superagonists on thyroidal uptake of 18F-fluorodeoxyglucose and radioiodide. ) Thyroid. 2011 Jul;21(7):783-92. doi: 10.1089/thy.2010.0394. Epub 2011 May 13〕 for human infertility and animal superovulation as well as targeted therapy and imaging of thyroid, ovarian, breast, prostate and testicular cancers.〔Adventure With Ventures. The Scientist, February 2006〕
==Technology==
The key to Trophogen's long acting superagonist proprietary patented technology is to carefully engineer new analogs to increase their affinity to the receptor. This is achieved by substituting crucial amino acids in the receptor binding domain, increasing affinity up to 100 fold. The addition of neoglycosylation sites extends the half-life of those analogs without extensions or subunit linkers, improving treatment convenience by reducing the number of injections. Trophogen's technology represents the first successful design of super active analogs of glycoprotein hormones that shows major increases in bioactivity and far exceeds results shown for other protein ligands 〔(Trophogen wants to score $10M, development deals. ) Washington Business Journal, March 2007.〕
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