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・ Tsiurupynsk Raion
・ TsIV
・ Tsiv-Gombori Range
・ Tsivdi
・ Tsivil River
・ Tsivilsk
・ Tsivilsk pig
・ Tsivilsky
・ Tsivilsky District
・ Tsivlos
・ Tsivoka
・ Tsivoka peyrierasi
・ Tsivoka simplicicollis
・ Tsivoka testaceipes
・ Tsivory
Tsix
・ TSJ Media
・ Tsjaka
・ Tsjibbe Gearts van der Meulen
・ Tsjuder
・ Tsk
・ Tsk Tsk Tsk
・ Tsk'weylecw'mc
・ Tskhenistsqali
・ Tskhinvali
・ Tskhinvali district
・ Tskhinvali Railway station
・ Tskhouk-Karckar
・ Tskitishvili
・ TSL


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Tsix : ウィキペディア英語版
Tsix

Tsix is a non-coding RNA gene that is antisense to the Xist RNA. Tsix binds Xist during X chromosome inactivation. The name Tsix comes from the reverse of Xist, which stands for X-inactive specific transcript.
== Background ==

Female mammals have two X chromosomes and males have one X and one Y chromosome. The X chromosome has many active genes. This leads to dosage compensation problems: the two X chromosomes in the female will create twice as many gene products as the one X in the male. To mitigate this, one of the X chromosomes is inactivated in females, so that each sex only has one set of X chromosome genes. The inactive X chromosome in cells of females is visible as a Barr body under the microscope. Males do not have Barr bodies as they only have one X chromosome.
Xist is expressed from one of the X chromosomes in females and serves to inactivate the other X chromosome during X inactivation. Many copies of Xist RNA bind the future inactivated X chromosome. Tsix prevents the accumulation of Xist on the future active female X chromosome to maintain the active euchromatin state of the chosen chromosome.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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