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Tumstatin
Tumstatin is a protein fragment cleaved from collagen that serves as both an antiangiogenic and proapoptotic agent. It has similar function to canstatin, endostatin, restin, and arresten, which also affect angiogenesis.〔http://www.copewithcytokines.de/cope.cgi?key=Tumstatin〕 Angiogenesis is the growth of new blood vessels from pre-existing blood vessels, and is important in tumor growth and metastasis. Angiogenesis is stimulated by many growth factors, the most prevalent of which is vascular endothelial growth factor (VEGF).〔http://www.merriam-webster.com/dictionary/angiogenesis.〕
==Structure and Function==
Tumstatin is a 28 kDa fragment cleaved from collagen type IV There are two subsegments of the peptide that are active; T3 peptide and T7 peptide.〔http://www.phoenixpeptide.com/catalog/pnxfoget.php?id=pnxnews_000000444&title=Compound&sum=Function.〕 The structure is very similar to that of endostatin, which is cleaved from collagen XVIII. The two proteins share 14% amino acid identity, making them very similar in structure.〔 It has been proven to inhibit many types of cells, including bovine endothelial cells, HeLa cells, endothelial cells, and Human umbilical vein endothelial cells (HUVEC) cells.〔〔〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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