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Tynorphin : ウィキペディア英語版
Tynorphin

Drugbox
| IUPAC_name = (2''S'')-2-amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1''H''-indol-3-yl)propanoic acid
" TITLE="(2''S'')-2-(2''S'')-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1''H''-indol-3-yl)propanoic acid
"> image = Tynorphin.svg
opioid peptide which is a potent and competitive inhibitor of the enkephalinase class of enzymes which break down the endogenous enkephalin peptides.〔cite journal | author = Yamamoto Y, Hashimoto J, Shimamura M, Yamaguchi T, Hazato T | title = Characterization of tynorphin, a potent endogenous inhibitor of dipeptidyl peptidaseIII | journal = Peptides | volume = 21 | issue = 4 | pages = 503–8 |date=April 2000 | pmid = 10822105 | doi = 10.1016/S0196-9781(00)00174-1| url = http://linkinghub.elsevier.com/retrieve/pii/S0196978100001741}}〕 It specifically inactivates dipeptidyl aminopeptidase III (DPP3) with very high efficacy, but also inhibits neutral endopeptidase (NEP), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE) to a lesser extent.〔 It has a pentapeptide structure with the amino acid sequence Val-Val-Tyr-Pro-Trp.
Tynorphin was discovered in an attempt to develop an enkephalinase inhibitor of greater potency than ()].〔
== See also ==

* Enkephalinase inhibitor

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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