翻訳と辞書 Words near each other ・ Ubayd Allah ibn Sulayman ・ Ubayd Allah ibn Ziyad ・ Ubayd Zakani ・ Ubayd-Allah ibn Abd-Allah ・ Ubayd-Allah ibn Jahsh ・ Ubaydah Bin Al Jarrah Air Base ・ Ubaydah ibn al-Harith ・ Ubaydullah Hussain ・ Ubaye ・ Ubaye Valley ・ Ubayyid ・ Ubazinho River ・ Ubaí ・ Ubaíra ・ UBB ・ UBB+1 ・ UBB.threads ・ Ubba ・ Ubbalagandi ・ Ubbalamadugu Falls ・ Ubbelohde viscometer ・ Ubbena ・ Ubbergen ・ Ubberud ・ Ubbeston ・ Ubbi ・ Ubbi dubbi ・ Ubbo Emmius ・ Ubbo-Emmius-Gymnasium ・ UBC (disambiguation) Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク UBB+1 ： ウィキペディア英語版 UBB+1 UBB+1 is shorthand for Ubiquitin-B+1, a frameshifted mutant arising from the Ubiquitin B gene. UBB+1 is thought to arise from molecular misreading, a poorly understood process. Molecular misreading introduces dinucleotide deletions (e.g. ΔGA, ΔGU) into mRNA transcripts. These deletions are not present in genomic DNA. UBB+1 has been observed in the hallmarks of Alzheimer's Disease, as well as other tauopathies and in polyglutamine diseases (e.g.Huntington's disease) but not in synucleinopathies (e.g.Parkinson's disease). Since its discovery it has been shown ''in vitro'' and ''in vivo'' that UBB+1 inhibits the proteasome and gives rise to downstream effects (e.g. a behavioral phenotype; impaired contextual memory). In non-neuronal cells UBB+1 also accumulates suggesting a functional role in non-neuronal diseases. UBB+1 can be truncated by yeast ubiquitin hydrolase 1 (YUH1) and ubiquitin C-terminal hydrolase L3 UCHL3 despite of the fact that the glycine at position 76 as been substituted for a tyrosine. == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「UBB+1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.