翻訳と辞書 Words near each other ・ Ubon UMT United F.C. ・ Ubon United F.C. ・ Ubongo ・ Ubora Towers ・ Ubort River ・ UBOS ・ Ubosot ・ UBot Studio ・ Ubowice ・ UBOX5 ・ Uboynaya River ・ UBP ・ UBP-302 ・ UBP1 ・ UBPC ・ UBQLN1 ・ UBQLN2 ・ UBR ・ UBR1 ・ UBR2 ・ UBR4 ・ UBR5 ・ Ubrangala ・ Ubraye ・ Ubre Blanca ・ UBreakiFix ・ Ubrique ・ Ubris ・ Ubristes ・ Ubrodowice Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク UBQLN1 ： ウィキペディア英語版 UBQLN1 Ubiquilin-1 is a protein that in humans is encoded by the ''UBQLN1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29979 )〕 Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation. ==Possible Role In Preventing Alzheimers Disease== Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.〔 Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease. Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「UBQLN1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.