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・ Upland Island Wilderness
・ Upland Lawn
・ Upland moa
・ Upland Mutual Insurance Company
・ Upland Outlaws
・ Upland Park
・ Upland pipit
・ Upland rice
・ Upland sandpiper
・ Upland South
・ Upland station
・ Upland Unified School District
・ Upland, California
・ Upland, Indiana
・ UPF
UPF1
・ UPF2
・ UPF3A
・ UPF3B
・ Upfade
・ Upfield
・ Upfield Bike Path
・ Upfield railway line
・ Upfield railway station
・ Upfield, Victoria
・ Upflow anaerobic sludge blanket digestion
・ Upfront
・ Upfront & Down Low
・ Upfront (David Sanborn album)
・ Upfront (John Miles album)


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UPF1 : ウィキペディア英語版
UPF1

Regulator of nonsense transcripts 1 is a protein that in humans is encoded by the ''UPF1'' gene.
== Function ==

This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5976 )

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「UPF1」の詳細全文を読む



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