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UPGMA (Unweighted Pair Group Method with Arithmetic Mean) is a simple agglomerative (bottom-up) hierarchical clustering method. It is one of the most popular methods in ecology for the classification of sampling units (such as vegetation plots) on the basis of their pairwise similarities in relevant descriptor variables (such as species composition).〔Legendre, P. and Legendre, L. 1998. Numerical Ecology. Second English Edition. Developments in Environmental Modelling 20. Elsevier, Amsterdam.〕 In bioinformatics, UPGMA is used for the creation of phenetic trees (phenograms). In a phylogenetic context, UPGMA assumes a constant rate of evolution (molecular clock hypothesis), and is not a well-regarded method for inferring relationships unless this assumption has been tested and justified for the data set being used. UPGMA was initially designed for use in protein electrophoresis studies, but is currently most often used to produce guide trees for more sophisticated phylogenetic reconstruction algorithms. The UPGMA algorithm constructs a rooted tree (dendrogram) that reflects the structure present in a pairwise similarity matrix (or a dissimilarity matrix). At each step, the nearest two clusters are combined into a higher-level cluster. The distance between any two clusters A and B is taken to be the average of all distances between pairs of objects "x" in A and "y" in B, that is, the mean distance between elements of each cluster: :: The method is generally attributed to Sokal and Michener. Fionn Murtagh found a time optimal time algorithm to construct the UPGMA tree. ==See also== *Neighbor-joining *Cluster analysis *Single-linkage clustering *Complete-linkage clustering *Hierarchical clustering *Models of DNA evolution *Molecular clock 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「UPGMA」の詳細全文を読む スポンサード リンク
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