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・ Vawnpayit
・ VAWS
・ Vawter Hall and Old President's House
・ Vawter Park Village
・ Vawter, Minnesota
・ VAX
・ Vax (disambiguation)
・ Vax (vacuum)
・ Vauxtin
・ Vav
・ Vav (protein)
・ Vav (Vidhan Sabha constituency)
・ Vav Darreh
・ VAV Life Sciences
・ Vav, Gujarat
VAV1
・ VAV2
・ VAV3
・ Vava (Babušnica)
・ Vava II
・ Vava Mario Yagalo
・ Vava Suresh
・ Vava Voom
・ Vavad
・ Vavad, India
・ Vavad, Iran
・ Vavaea
・ Vavaea bantamensis
・ Vavakkad
・ Vavali


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VAV1 : ウィキペディア英語版
VAV1

Proto-oncogene vav is a protein that in humans is encoded by the ''VAV1'' gene.
== Function ==

The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7409 )

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「VAV1」の詳細全文を読む



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