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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Viperin ： ウィキペディア英語版 Viperin Viperin (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible), also known as RSAD2 (radical SAM domain-containing 2), is a multifunctional protein in viral processes, which could be induced in a variety of cell types by different cellular factors, such as type I II and III interferon, DNA and RNA viral proteins, poly (I: C) and polysaccharide. Recently, it is reported that viperin could be induced in either IFN-dependent or IFN-independent pathway. == Function == Viperin is a cellular protein which could inhibit many DNA and RNA viruses such as CHIKV, HCMV, HCV, DENV, WNV, SINV, influenza, HIV LAI strain, and so on. Initially identified as an IFN-γ induced antiviral protein in human cytomegalovirus (HCMV) infected macrophages, viperin is reported that it could be induced by HCMV glycoprotein B in fibroblasts but inhibits HCMV viral infection and down-regulates viral structural proteins, which is essential for viral assembling and maturation. The mechanism of how the virus protein induces viperin against itself is still not clear. However, the viral induced redistribution of Viperin is also found in HCMV infected cells, which may reflect the mechanism of virus evading antiviral activities of Viperin. Viperin could also be induced, and then interact with HCMV viral proteins and relocate to mitochondria in HCMV viral infected cells, and finally enhance viral infectivity by the disrupted cellular metabolism. In the inhibition of influenza virus budding and release, viperin could disrupt the lipid rafts on cell plasma membrane by decreasing the enzyme activities of farnesyl diphosphate synthase (FPPS), which is an essential enzyme in isoprenoid biosynthesis pathway. Besides, viperin can also inhibit the viral replication of HCV via the interaction with host protein hVAP-33 and NS5A and disruption of the formation of the replication complex. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Viperin」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.