翻訳と辞書 Words near each other ・ Voryema Bay ・ Vorys, Sater, Seymour and Pease ・ Vorzel ・ Vorá River ・ Voráček ・ Vorë ・ Vorë Train Station ・ Vorța ・ Vos ・ Vos (Danish band) ・ Vos (surname) ・ Vos Iz Neias? ・ Vos TV (Canal 14) ・ Vos'moy Mart Rocks ・ Vosakou Monastery ・ Vosaroxin ・ Vosberg ・ Vosbles ・ Vosburg ・ Vosburg Turning Mill Complex ・ Vosburg v. Putney ・ Vosburgh ・ Vosburgh Stakes ・ Voscuore Sendai ・ Vose ・ Vose Seminary ・ Vose' ・ Vose' District ・ Vosegus ・ Vosek, Pesnica Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Vosaroxin ： ウィキペディア英語版 Vosaroxin Vosaroxin (AG-7352, SPC-595, SNS 595, voreloxin) is a topoisomerase II inhibitor causing site-selective DNA damage.It is under phase III clinical trial investigation for acute myelogenous leukemia (AML) and ovarian cancer sponsored by Sunesis.〔(【引用サイトリンク】 publisher = Selleck Chemicals )〕 == Mechanism of action== Vosaroxin is a naphthyridine analog of the anticancer quinolone derivatives (AQDs), a class of compounds that has not been used previously for the treatment of cancer. Topoisomerase II enzymes are essential for the survival of eukaryotic cells. Vosaroxin hinders the reunion of topoisomerase II-induced double-strand breaks at selective sites in DNA, resulting in G2 arrest and cell death by apoptosis.〔(【引用サイトリンク】 publisher = Sunesis )〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Vosaroxin」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.