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Class III PI 3-kinase
Class III PI 3-kinase is a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.
There is only one known class III PI 3-kinase, Vps34, which is also the only PI 3-kinase expressed in all eukaryotic cells. In humans it is encoded by the PIK3C3 gene. In human cells Vps34 associates with a regulatory subunit, p150.
==Substrate specificity==
Vps34 is more accurately described as a phosphatylinositol 3-kinase. ''In vivo'' Vps34 can phosphorylate only Phosphatidylinositol to form phosphatidylinositol (3)-phosphate (PtdIns(3)P).
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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