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・ Way to Your Heart
・ Way Too Cool 50 Kilometer
・ Way Too Early
・ Way Too Far
・ Way Up High
・ Way up structure
・ Way Up Thar
・ Way Up There
・ Way Upstate and the Crippled Summer, pt. 1
・ Way Upstate and the Crippled Summer, pt. 2
・ Way Upstream
・ Way Way General Store
・ Way We Are (song)
・ Way, Mississippi
・ Way, St Giles in the Wood
WAY-100,135
・ WAY-100,635
・ WAY-161503
・ WAY-181,187
・ WAY-208,466
・ WAY-213,613
・ WAY-267,464
・ WAY-317,538
・ WAY-629
・ WAY-FM
・ WAY-FM Network
・ Way...Way Out
・ Way2SMS.com
・ Waya
・ Waya (disambiguation)


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WAY-100,135 : ウィキペディア英語版
WAY-100,135

WAY-100,135 is a serotonergic drug of the phenylpiperazine family which is used in scientific research. It acts as potent 5-HT1A receptor antagonist, and was originally believed to be highly selective, but further studies have demonstrated that it also acts as a partial agonist of the 5-HT1D receptor (pKi = 7.58; virtually the same affinity for 5-HT1A), and to a much lesser extent, of the 5-HT1B receptor (pKi = 5.82). These findings may have prompted the development of the related compound WAY-100,635, another purportedly selective and even more potent 5-HT1A antagonist, which was synthesized shortly thereafter. However, WAY-100,635 turned out to be non-selective as well, having been shown to act additionally as a potent D4 receptor agonist later on.
== See also ==

* WAY-100,635

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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