翻訳と辞書 Words near each other ・ Wire bonding ・ Wire brush ・ Wire Building ・ Wire Cache Provincial Park ・ Wire chamber ・ Wire cutter (jeep) ・ Wire Daisies ・ Wire Daisies (album) ・ Wire Daisies discography ・ Wire data ・ Wire discography ・ Wire drawing ・ Wire FM ・ Wire Fox Terrier ・ WIPI1 ・ WIPI2 ・ Wipim Airport ・ Wiping ・ Wipit ・ WIPK ・ Wipkingen ・ Wipkingen Tunnel ・ WIPM ・ Wipo ・ WIPO Convention ・ WIPO Copyright and Performances and Phonograms Treaties Implementation Act ・ WIPO Copyright Treaty ・ Wipo of Burgundy ・ WIPO Performances and Phonograms Treaty ・ WIPO ST.3 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク WIPI2 ： ウィキペディア英語版 WIPI2 WD repeat domain phosphoinositide-interacting protein 2 is a protein that in humans is encoded by the ''WIPI2'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26100 )〕 == Function == WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.〔〔 WIPI2 is the mammalian homolog of Atg18, not Atg21, along with the closely related protein, WIPI1. WIPI2 mRNA is readily detectable in several commonly used laboratory cell lines (HEK293A, HeLa, A431) and several cancer cell lines, while WIPI1 expression is limited to cancer cells. The Atg proteins regulate autophagy, which is a lysosomal degradation pathway required for maintaining cell health, surviving periods of nutrient deprivation and also plays a role in cancer, neurodegeneration and immune responses to a diverse range of pathogens. WIPI2 is recruited early to the forming autophagosome, along with DFCP-1, ULK-1 and Atg16, where it positively regulates the lipidation of Atg8 (LC3). Interestingly, this is not true for WIPI1. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「WIPI2」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.