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WRAP53 WRAP53 (also known as WD40-encoding RNA antisense to ''p53'') is a gene implicated in cancer development. The name was coined in 2009 to describe the dual role of this gene, encoding both an antisense RNA that regulates the ''p53'' tumor suppressor and a protein involved in DNA repair, telomere elongation and maintenance of nuclear organelles Cajal bodies (Figure 1).〔Farnebo, M. Wrap53, a novel regulator of p53. Cell Cycle 8, 2343-2346 (2009).〕〔Venteicher, A. S. et al. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science 323, 644-648, doi:10.1126/science.1165357 (2009).〕〔Tycowski, K. T., Shu, M. D., Kukoyi, A. & Steitz, J. A. A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles. Mol Cell 34, 47-57, doi:10.1016/j.molcel.2009.02.020 (2009).〕 ==Localisation== The ''WRAP53'' gene is localized on chromosome 17p13.1 and contains 13 exons, including three alternative starting exons (1α, 1β and 1γ) generating at least three gene products. The ''WRAP53'' gene partially overlaps the ''p53'' tumor suppressor gene in a head-to-head orientation.
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