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|Section2= |Section3= }} XCT790 is a potent and selective inverse agonist ligand of the estrogen-related receptor alpha. Independent of its inhibition of ERRα, XCT790 is a potent mitochondrial electron transport chain uncoupler. ==Mitochondrial electron transport chain uncoupling effect== XCT790 has been shown to uncouple oxygen consumption from ATP production in mitochondria at very low, nanomolar-range doses independently of ERRα expression. Its effects are similar to proton ionophores such as FCCP, which disrupt mitochondrial transmembrane electrochemical gradients. This uncoupling leads to a fast drop in ATP production and, consequently, a prompt activation of AMPK. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「XCT790」の詳細全文を読む スポンサード リンク
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