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Y linkage
In mammals, Y-linkage, also known as holandric inheritance, is the determination of a phenotypic trait by an allele (or gene) on the Y chromosome.
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Because the Y-chromosome is small and does not contain many genes, few traits are Y-linked, and Y-linked diseases are rare. Since the only humans who have a Y chromosome are males, Y-linked traits are passed only from father to son, with no interchromosomal genetic recombination.
Y-Chromosome deletions are a frequent genetic cause of male infertility. Having hairy ears was once thought to be a Y-linked trait in humans,〔(Online Mendelian Inheritance of Man ), HAIRY EARS, Y-LINKED, although see (HAIRY EARS ).〕 but that hypothesis has been discredited.
==Genes known to be contained on the Y chromosome==
As of the year 2000, a number of genes were known to be Y-linked, including:
*ASMTY (acetylserotonin methyltransferase),
*TSPY (testis-specific protein),
*IL3RAY (interleukin-3 receptor),
*SRY (sex-determining region),
*TDF (testis determining factor),
*ZFY (zinc finger protein),
*PRKY (protein kinase, Y-linked),
*AMGL (amelogenin),
*CSF2RY (granulocyte-macrophage, colony-stimulating factor receptor, alpha subunit on the Y chromosome),
*ANT3Y (adenine nucleotide translocator-3 on the Y),
*SOX21 (known to cause baldness),
*AZF2 (azoospermia factor 2),
*BPY2 (basic protein on the Y chromosome),
*AZF1 (azoospermia factor 1),
*DAZ (Spermatogenes is deleted in azoospermia),
*RBM1 (RNA binding motif protein, Y chromosome, family 1, member A1),
*RBM2 (RNA binding motif protein 2), and
*UTY (ubiquitously transcribed TPR gene on Y chromosome).
*USP9Y
*AMELY
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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