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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク YPEL3 ： ウィキペディア英語版 YPEL3 Yippee-like 3 (Drosophila) is a protein that in humans is encoded by the YPEL3 gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/gene/83719 )〕 YPEL3 has growth inhibitory effects in normal and tumor cell lines. One of five family members (YPEL1-5), YPEL3 was named in reference to its Drosophila melanogaster orthologue.〔 Initially discovered in a gene expression profiling assay of p53 activated MCF7 cells, induction of YPEL3 has been shown to trigger permanent growth arrest or cellular senescence in certain human normal and tumor cell types.〔 DNA methylation of a CpG island near the YPEL3 promoter as well as histone acetylation may represent possible epigenetic mechanisms leading to decreased gene expression in human tumors.〔 == Gene location and protein structure == Human ''YPEL3'' is located on the short arm of chromosome 16 (p1611.2) and covers 4.62kb from 30015754 to 30011130 on the reverse strand.〔〔http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&l=YPEL3〕 The drosophilia Yippee protein was identified as a putative zinc finger motif containing protein exhibiting a high degree of conservation among the cysteines and histidines. Zinc fingers function as structural platforms for DNA binding. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「YPEL3」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.