翻訳と辞書 Words near each other ・ Yên Định, Bắc Giang ・ Yêndum ・ Yêu một người – Sống bên một người ・ YWCA Site ・ YWCA USA ・ YWCA Youngstown ・ YWCA, Phillis Wheatley Branch ・ YWCA-Rolling Bay Route ・ YWCA-YMCA Guides and Scouts of Norway ・ YWCA-YMCA of Sweden ・ YWHAB ・ YWHAE ・ YWHAG ・ YWHAH ・ YWHAQ ・ YWHAZ ・ YWTD domain of low-density lipoprotein receptor ・ YX ・ YX Energi ・ YXA ・ Yxaiio ・ Yxlan ・ YXORP ・ Yxskaftkälen ・ Yxsmedsgränd ・ Yxta Maya Murray ・ Yxtaholm Castle ・ YXY ・ Yxygodes ・ YY Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク YWHAZ ： ウィキペディア英語版 YWHAZ 14-3-3 protein zeta/delta (14-3-3ζ) is a protein that in humans is encoded by the ''YWHAZ'' gene on chromosome 8.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7534 )〕 The protein encoded by this gene is a member of the 14-3-3 protein family and a central hub protein for many signal transduction pathways.〔 14-3-3ζ is a major regulator of apoptotic pathways critical to cell survival and plays a key role in a number of cancers and neurodegenerative diseases.〔 ==Structure== 14-3-3 proteins generally form ~30 kDa-long homo- or heterodimers. Each of the monomers are composed of 9 antiparallel alpha helices. Four alpha-helices (αC, αE, αG, and αI) form an amphipathic groove that serves as the ligand binding site, which can recognize three types of consensus binding motifs: RXX(pS/pT)XP, RXXX(pS/pT)XP, and (pS/pT)X1-2-COOH (where pS/pT represents phosphorylated serine/threonine). In addition to these primary interactions, the target protein can also bind outside the groove via secondary interactions. In particular, the crystallized structure of 14-3-3ζ forms a cup-shaped dimer when complexed with CBY.〔 The ''YWHAZ'' gene encodes two transcript variants which differ in the 5' UTR but produce the same protein.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「YWHAZ」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.