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ZAP70
ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of T cells and natural killer cells. It is part of the T cell receptor, and plays a critical role in T-cell signaling. Its molecular weight is 70 kDa, and it is a member of the protein-tyrosine kinase family.
==Clinical significance==
ZAP-70 in B cells is used as a prognostic marker in identifying different forms of chronic lymphocytic leukemia (CLL). DNA analysis has distinguished two major types of CLL, with different survival times. CLL that is positive for the marker ZAP-70 has an average survival of 8 years. CLL that is negative for ZAP-70 has an average survival of more than 25 years. Many patients, especially older ones, with slowly progressing disease can be reassured and may not need any treatment in their lifetimes.
In systemic lupus erythematosus, the Zap-70 receptor pathway is missing and Syk takes its place.〔NEJM 365:2110〕
ZAP70 deficiency results in a form of immune deficiency.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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