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ZS-9 (sodium zirconium cyclosilicate) is a selective oral sorbent that traps potassium ions throughout the gastrointestinal tract. It is being developed by ZS Pharma for the treatment of hyperkalemia (elevated serum potassium levels).〔 == Background == (詳細はrenal function, potassium-sparing diuretics and renin-angiotensin system blockers (e.g., ACE inhibitors, angiotensin receptor blockers, spironolactone) and diabetes mellitus.〔〔〔〔 There is no universally accepted definition of what level of hyperkalemia is mild, moderate, or severe.〔 However, if hyperkalemia causes any ECG change it is considered a medical emergency〔 due to a risk of potentially fatal abnormal heart rhythms (arrhythmia) and is treated urgently.〔 serum potassium concentrations greater than 6.5 to 7.0 mmol/L in the absence of ECG changes are managed aggressively.〔 Hyperkalemia, particularly if severe, is a marker for an increased risk of death.〔 However, there is disagreement regarding whether a modestly elevated serum potassium level directly causes significant problems. One viewpoint is that mild to moderate hyperkalemia is an secondary effect that denotes significant underlying medical problems.〔 Accordingly, these problems are both proximate and ultimate causes of death,〔 and adjustment of potassium may not be helpful. Alternatively, hyperkalemia may itself be an independent risk factor for cardiovascular mortality.〔 Several approaches are used in treatment of hyperkalemia,〔 but currently the only product approved by the U.S. Food and Drug Administration (FDA) to treat hyperkalemia is sodium polystyrene sulfonate (Kayexalate),〔 an organic ion-exchange resin that nonspecifically binds cations (e.g., calcium, potassium, magnesium) in the gastrointestinal tract. The effectiveness of sodium polystyrene sulfonate has been questioned: a study in healthy subjects showed that laxatives alone were almost as effective in increasing potassium secretion as laxatives plus Kayexalate.〔 In addition, use of sodium polystyrene sulfonate, particularly if formulated with high sorbitol content, is uncommonly but convincingly associated with colonic necrosis.〔〔〔〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「ZS-9」の詳細全文を読む スポンサード リンク
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