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Zebularine
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Zebularine : ウィキペディア英語版
Zebularine

Zebularine is a nucleoside analog of cytidine. It is a "transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo."〔(【引用サイトリンク】title=pyrimidin-2-one beta-ribofuranoside - Compound Summary )
In a small study of mice with a defective ''Adenomatous polyposis coli'' gene, oral administration of zebularine to males had no effect on the overall methylation of DNA or the number of polyps, but in females the average number of polyps was reduced from 58 to 1. It has therefore been suggested for drug use as a prototype of epigenetic therapy for cancer chemoprevention.
== References ==



抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Zebularine」の詳細全文を読む



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