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acedapsone
Acedapsone (INN) is an antimicrobial drug, which also has antimalarial activity.
Acedapsone, or 1399 F, is a diacetyl compound, derived from dapsone. It was synthesized and developed in 1937 by Ernest Fourneau and his team in the pharmaceutical chemistry laboratory of Pasteur Institute,〔 E. Fourneau, J. et Th. Tréfouël, F. Nitti, D. Bovet, « Chimiothérapie de l'infection pneumococcique par la di-(p-acétylaminophényl)-sulfone (1399 F) », ''C. r. Acad. sci''., vol. 205, 1937, pp. 299-300.〕 and it was marketed as Rodilone by the Rhône-Poulenc company.〔 Marcel Delépine, ''Ernest Fourneau (1872-1949) : Sa vie et son œuvre'', extrait du Bulletin de la Société chimique de France, Masson et Cie, 1950, pp. 64-67.〕
It is a long-acting prodrug of dapsone. It is used for treating leprosy.
It crystallises as pale yellow needles from diethyl ether, and as leaflets from dilute ethanol. It is slightly soluble in water.
==References==
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