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Adaptins are proteins that mediate the formation of vesicles by clathrin-coated pits, through interaction with membrane-bound receptors. There are several types of adaptin, each related to a different group of such receptors. Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin. Adaptins cluster to form the AP2 complex. The Adaptin complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma): * complex 1 * * AP1B1 * * AP1G1 * * AP1G2 * * AP1M1 * * AP1M2 * * AP1S1 * * AP1S2 * * AP1S3 * complex 2 * * AP2A1 * * AP2A2 * * AP2B1 * * AP2M1 * * AP2S1 * complex 3 * * AP3B1 * * AP3B2 * * AP3M1 * * AP3M2 * * AP3S1 * * AP3S2 * complex 4 * * AP4B1 * * AP4E1 * * AP4M1 * * AP4S1 * complex 5 * * complex 5 has been discovered at the university of Alberta, Canada, little is yet known of the internal constructs that make up the complex. ==References== * Alberts, Johnson, Lewis, Raff, Roberts, Walter: ''Molecular Biology of the Cell'', 4th edition (2002), Garland Science. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「adaptin」の詳細全文を読む スポンサード リンク
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