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adrenomedullin
Adrenomedullin (ADM or AM) is a vasodilator peptide hormone of uncertain significance in human health and disease. It was initially isolated in 1993 from pheochromyctoma, a tumor of the adrenal medulla: hence the name.
In humans ADM is encoded by the ''ADM'' gene. ADM is a peptide expressed by all tissues, and found in the circulation. A similar peptide named adreomedullin2 was reported in rats in 2004 which exhibits a similar function.
== Function ==
AM may function as a hormone in circulation control because it is found in blood in a considerable concentration. It was initially identified as a vasodilator, some have cited this as the most potent endogenous vasodilatory peptide found in the body. Differences in opinion regarding the ability of AM to relax vascular tone arises from the differences in the model system used.
Other effects of AM include upregulating angiogenesis and increasing the tolerance of cells to oxidative stress and hypoxic injury. AM is seen as a positive influence in diseases such as hypertension, myocardial infarction, chronic obstructive pulmonary disease and other cardiovascular diseases, whereas it can be seen as a negative factor in potentiating the ability of cancerous cells to extend their blood supply and thereby cause cell proliferation.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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