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agatoxin
Agatoxins are a class of chemically diverse polyamine and peptide toxins which are isolated from the venom of various spiders. Their mechanism of action includes blockade of glutamate-gated ion channels, voltage-gated sodium channels, or voltage-dependent calcium channels. Agatoxin is named after the funnel web spider (''Agelenopsis aperta'') which produces a venom containing several agatoxins.
== Isolation ==
The venom of the ''Agelenopsis aperta'' is located in two glands, which are located in the two fang bases. Ejection of the venom takes place via contraction of surrounding muscles. To obtain this venom, the spider is milked by electrical stimulation. The crude venom is dissolved in an EDTA plasma to avoid proteolysis. Purification of the agatoxin is accomplished by a HPLC procedure.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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