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| antiestrogen ： ウィキペディア英語版 |
antiestrogen
An antiestrogen is a substance that blocks the production or utilization of estrogens,〔,〕 or inhibits their effects. Estrogens are the family of hormones that promote the development and maintenance of female sex characteristics.
Antiestrogens like tamoxifen can promote an invasive phenotype in estrogen receptor (ER)-positive breast cancer cells with deficient intercellular adhesion.
Although aromatase inhibitors could be considered antiestrogens by some definitions, they are often considered to be a distinct class. Aromatase inhibitors reduce the ''production'' of estrogen, while the term "antiestrogen" is usually reserved for agents reducing the ''response'' to estrogen.
Hot flashes, osteoporosis, breast atrophy, and vaginal dryness can be side effects of antiestrogens.
==See also==
* Selective estrogen receptor modulator
* Antiandrogen
* Antiprogestin
* Antiestrogenic diet
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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