|
Artesunate (AS) is a medication used to treat malaria. It is water-soluble and may therefore be given by injection. It is a semi-synthetic derivative of artemisinin. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. ==Medical uses== The World Health Organization recommends intramuscular or intravenous artesunate as the first line treatment for severe malaria. Artesunate was shown to prevent more deaths from severe malaria than quinine in two large multicentre randomized controlled trials from Africa and Asia. A subsequent systematic review of seven randomized controlled trials found this beneficial effect to be consistent across all trials. For severe malaria during pregnancy, there is less certainty about the safety of artesunate during the first trimester but artesunate is recommended as first-line therapy during the second and third trimesters.〔WHO (2007). (Assessment of the safety of artemisinin compounds in pregnancy ). World Health Organization, Geneva.〕 Artesunate is also used to treat less severe forms of malaria when it can be given orally, but should always be taken with a second antimalarial such as mefloquine or amodiaquine to avoid the development of resistance.〔 While artesunate is used primarily as treatment for malaria, there is some evidence that it may also have some beneficial effects in ''Schistosoma haematobium'' infection, but this needs confirming in large randomized trials. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「artesunate」の詳細全文を読む スポンサード リンク
|