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benactyzine
Benactyzine is an anticholinergic drug that was used as an antidepressant in the treatment of depression and associated anxiety before it was pulled from the U.S. market by the FDA due to its ineffectiveness.〔Shorter, E., Looking backwards: a possible new path for drug discovery in psychopharmacology. Nat Rev Drug Discov 2002, 1 (12), 1003-1006.〕
Its use for these indications was limited by side effects such as dry mouth and nausea, and at high doses it can cause more severe symptoms such as deliriant and hallucinogenic effects.〔
Brand names have included: Suavitil, Phebex, Phobex, Cedad, Cevanol, Deprol, Lucidil, Morcain, Nutinal, Parasan. While there was some tentative evidence when combined with meprobamate with the medication no longer available it is not clinical important.
==History==
Benactyzine was brought to market in the US in 1957 by Merck under the tradename, Suavitil.〔Smith, Mickey C., PhD. (Principles of Pharmaceutical Marketing ), Third Edition. 3rd ed. New York: Routledge, 2013. Print. ISBN 9781317940715〕
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