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Benzphetamine (Didrex) is a substituted amphetamine used short-term along with a doctor-approved, reduced-calorie diet, exercise, and behavioral program for weight loss. It is prescribed for obesity in individuals who have been unable to lose weight through exercise and dieting alone. Benzphetamine is an anorectic, primarily promoting weight loss through reduced appetite. Benzphetamine also slightly increases metabolism. It's mechanism of action is not fully known, but is believed to be related to that of amphetamine.〔http://www.drugbank.ca/drugs/DB00865〕 == Pharmacology == Benzphetamine is a sympathomimetic amine and is classified as an anorectic. The drug's main function is to reduce appetite, which in turn reduces caloric intake. Although the mechanism of action of the sympathomimetic appetite suppressants in the treatment of obesity is not fully known, these medications have pharmacological effects similar to those of amphetamines. Amphetamine and related sympathomimetic medications (such as benzphetamine) are thought to stimulate the release of norepinephrine and/or dopamine from storage sites in nerve terminals of the lateral hypothalamic feeding center, thereby producing a decrease in appetite. This release is mediated through the binding of benzphetamine to VMAT2 and inhibiting its function, causing a release of these neurotransmitters into the synaptic cleft through their reuptake transporters. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class. Benzphetamine has a half-life of 4-6 hours. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「benzphetamine」の詳細全文を読む スポンサード リンク
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