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bimatoprost : ウィキペディア英語版
bimatoprost

Bimatoprost (marketed in the U.S., Canada and Europe by Allergan, under the trade name Lumigan) is a prostaglandin analog/prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. In December 2008, the indication to lengthen eyelashes was approved by the U.S. Food and Drug Administration (FDA); the cosmetic formulation of bimatoprost is sold as Latisse .
==Cosmetic use==
In patients using ophthalmic prostaglandins such as travoprost and latanoprost, it has been anecdotally noted that there had been an increase in diameter, density and length of eyelashes. Allergan initiated clinical trials investigating the usage of Lumigan as a cosmetic drug. On December 5, 2008, the FDA Dermatologic and Ophthalmic Drugs Advisory Committee voted to approve bimatoprost for the cosmetic use of darkening and lengthening eyelashes. The medical term for this is treatment of hypotrichosis, however, the FDA approval is for purely cosmetic purposes.〔The Pink Sheet: () Lauren Smith December 15, 2008; Volume 70, Number 050,Page 〕
For cosmetic purposes, it is administered once daily by applying the solution to the skin at the base of the eyelash.
According to Allergan's package labeling, users of its Latisse cosmetic product didn't develop darker irises in clinical studies; however, "patients should be advised about the potential for increased brown iris pigmentation which is likely to be permanent."〔Latisse prescribing information: ("Important Safety Information" )〕
Several cosmetics companies have released products based on prostaglandin analogs, as non-drug cosmetics.
* Age Intervention Eyelash by Jan Marini Skin Research
* RevitaLash by Athena Cosmetics Corp.
These companies have been sued by Allergan for patent infringement.〔 The FDA has seized Age Intervention Eyelash as an "unapproved and misbranded drug" because Jan Marini Skin Research promoted it as something that increases eyelash growth〔MSNBC: (FDA Seizes $2 Million Of Potentially Harmful SJ Eye Product ) KNTV-TV November 17, 2007 〕 and because it is "adulterated" with bimatoprost.〔Reuters: ("U.S. seizes discontinued eyelash product" ). Jim Wolf. November 16, 2007.〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「bimatoprost」の詳細全文を読む



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