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carvedilol
Carvedilol, sold under the brand name Coreg among others, is a nonselective beta blocker/alpha-1 blocker. It is used in the treatment of mild to severe congestive heart failure (CHF), left ventricular dysfunction (LVD) following heart attack in clinically stable patients, and high blood pressure.
Carvedilol was discovered by Fritz Wiedemann at Boehringer Mannheim and was initially approved in the U.S. in 1995, marketed as Coreg.〔U.S. Patent 4503067〕 On October 20, 2006, the FDA approved an extended-release formulation of carvedilol; it is marketed as Coreg CR.
== Medical use ==
Carvedilol is indicated in the management of congestive heart failure (CHF), commonly as an adjunct to angiotensin-converting-enzyme inhibitor (ACE inhibitors) and diuretics. It has been clinically shown to reduce mortality and hospitalizations in people with CHF. The mechanism behind its positive effect when used long-term in clinically stable CHF patients is not fully understood, but is thought to contribute to remodeling of the heart, improving upon its structure and function.
In addition, carvedilol is indicated in the treatment of hypertension. It can be used alone or with other anti-hypertensive agents. In the 2013 guideline, it is recommended as the drug of choice in people with histories of CHF and/or myocardial infarction.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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