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cefsulodin
Cefsulodin is a third-generation cephalosporin antibiotic with specific activity against ''Pseudomonas aeruginosa''. It has no significant activity against other Gram-negative bacteria and very limited activity against Gram-positive bacteria and anaerobic bacteria. Cefsulodin was first synthesized and patented by the Takeda Pharmaceutical Company in 1977. In 2002, Takeda stopped production of cefsulodin. Many years of low-stability cefsulodin production has led to a widespread reduction of laboratory and research uses. Current attempts (i.e. IDEXX Laboratories) of increasing purity and stability of cefsulodin center around recrystallization. Typically, the process entails: Cefsulodin is dissolved in an organic solvent, sodium ions, water, or any mixture thereof, then subsequently recrystallized through separation of the unwanted fraction. Recently, TOKU-E has found the main cause of cefsulodin instability stems from one key impurity in 7-aminocephalosporanic acid, a raw material used in the synthesis of cefsulodin. To produce high-purity, high-stability cefsulodin, TOKU-E uses industrial HPLC to remove significant quantities of this impurity in 7-ACA and thus produces ultrapure, ultrastable, and ultrapotent cefsulodin.〔(), TOKU-E Technical Application Sheet.〕
== General use ==
Cefuslodin is most commonly used in cefsulodin-irgasan-novobiocin agar to select for ''Yersinia'' microorganisms.〔(【引用サイトリンク】url=http://www.fda.gov/Food/ScienceResearch/LaboratoryMethods/BacteriologicalAnalyticalManualBAM/ucm064575.htm )〕 This agar is most often used in water and beverage testing.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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