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Ceramidase (, ''acylsphingosine deacylase'', ''glycosphingolipid ceramide deacylase'') is an enzyme which cleaves fatty acids from ceramide, producing sphingosine (SPH) which in turn is phosphorylated by a sphingosine kinase to form sphingosine-1-phosphate (S1P). == Function == Ceramide, SPH, and S1P are bioactive lipids that mediate cell proliferation, differentiation, apoptosis, adhesion, and migration. Presently, 7 human ceramidases encoded by 7 distinct genes have been cloned:〔 * acid ceramidase (ASAH1) – cell survival * neutral ceramidase (ASAH2, ASAH2B, ASAH2C) – protective against inflammatory cytokines * alkaline ceramidase 1 (ACER1) – mediating cell differentiation by controlling the generation of SPH and S1P * alkaline ceramidase 2 (ACER2) – important for cell proliferation and survival * alkaline ceramidase 3 (ACER3) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「ceramidase」の詳細全文を読む スポンサード リンク
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