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chymosin
Chymosin or rennin is a protease found in rennet. It is produced by newborn ruminant animals in the lining of the fourth stomach to curdle the milk they ingest, allowing a longer residence in the bowels and better absorption. It is widely used in the production of cheese. Bovine chymosin is now produced recombinantly in , ''Aspergillus niger var awamori'', and as alternative resource.
==Occurrence==
Chymosin is produced by ruminant animals in the lining of the abomasum. Chymosin is produced by gastric chief cells in young ruminants and some other newborn animals to curdle the milk they ingest, allowing a longer residence in the bowels and better absorption. Chymosin is also produced by gastric chief cells in human infants.
Some other non-ruminant species, including pigs, cats, and seals, produce it.〔Staff, Online Mendelian Inheritance in Man (OMIM) Database. Last updated February 21, 1997 (Chymosin pseudogene; CYMP prochymosin, included, in the OMIM )〕
Humans have a pseudogene for chymosin that does not generate a protein, found on chromosome 1.〔〔Fox, P. F. Google books. (Cheese: Chemistry, Physics and Microbiology: Volume 1: General Aspects. )〕 Humans have other proteases to digest milk, such as pepsin and lipase.〔Ian R. Sanderson M.D. and W. Allan Walker (Development of the Gastrointestinal Tract ) pmph usa 1999. ISBN 155009081X〕
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