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clastogen
== Biology ==
A clastogen in biology is a mutagenic agent giving rise to or inducing disruption or breakages of chromosomes, leading to sections of the chromosome being deleted, added, or rearranged.〔Rosefort C., Fauth E., Zankl H.: Micronuclei induced by aneugens and clastogens in mononucleate and binucleate cells using cytokinesis block assay. Mutagenesis 19, pp. 277-284 (2004)〕 This process is a form of mutagenesis, and can lead to carcinogenesis, as cells that are not killed by the clastogenic effect may become cancerous. Known clastogens include acridine yellow, benzene, ethylene oxide, arsenic, phosphine and mimosine. Exposure to clastogens increases frequency of abnormal germ cells in paternal males, contributing to developmental effects in the fetus upon fertilization.
: Illustrative sentence: "This leads to the conclusion that a chemical that fails to induce a significant response in an ''in vitro'' clastogenicity assay is unlikely to be clastogenic ''in vivo,'' in bone marrow assays."〔Rose, John. (1988). ( ''Environmental Toxicology: Current Developments,'' p. 64. )〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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