|
Clofazimine is a fat-soluble iminophenazine dye used in combination with rifampicin and dapsone as multidrug therapy (MDT) for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat ''Mycobacterium avium'' infections in AIDS patients and ''Mycobacterium avium paratuberculosis'' infection in Crohn's disease patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum (ENL). (From AMA Drug Evaluations Annual, 1993, p1619). The drug is given as an alternative to patients who can not tolerate the effects of dapsone for tuberculosis.〔Clinical Microbiology Made Ridiculously Simple〕 It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. ==Side effects== Clofazimine produces pink to brownish skin pigmentation in 75-100% of patients within a few weeks, as well as similar discoloration of most bodily fluids and secretions. These discolorations are reversible but may take months to years to disappear. The prescribing information indicates that several patients have developed depression as a result of this chronic skin discoloration, resulting in two suicides. Cases of icthyosis and skin dryness are also reported in response to this drug (8%-28%), as well as rash and pruritis (1-5%). 40-50% of patients develop gastrointestinal intolerance. Rarely, patients have died from bowel obstructions and intestinal bleeding, or required abdominal surgery to correct the same problem. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「clofazimine」の詳細全文を読む スポンサード リンク
|