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Clomipramine (trademarked as Anafranil and Clofranil) is a tricyclic antidepressant (TCA). It was developed in the early 1960s〔CH Patent 371800 Verfahren zur Herstellung von neuen N-heterocyclischen Verbindungen (A process for the preparation of novel N-heterocyclic compounds)〕 by the Swiss drug manufacturer Geigy (now known as Novartis) and has been in clinical use worldwide ever since. It is the 3-chlorinated derivative of the earlier tricyclic, imipramine. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. ==Medical uses== Clomipramine has a number of uses in medicine including in the treatment of: * Obsessive–compulsive disorder (OCD) which is its only U.S. FDA-labelled indication. Other regulatory agencies (such as the TGA of Australia and the MHRA of the UK) have also approved clomipramine for this indication. * Major depressive disorder (MDD) a popular off-label use in the US. It is approved by the Australian TGA and the United Kingdom MHRA for this indication.〔〔〔〔 Some have suggested the possible superior efficacy of clomipramine compared to other antidepressants in the treatment of MDD, although at the current time the evidence is insufficient to adequately substantiate this claim. * Panic disorder with or without agoraphobia. * Body dysmorphic disorder * Cataplexy associated with narcolepsy. Which is a TGA & MHRA-labelled indication for clomipramine.〔〔 * Premature ejaculation * Depersonalization disorder * Chronic pain with or without organic disease, particularly headache of the tension type. * Sleep paralysis, with or without narcolepsy * Enuresis (involuntary nightly urinating in sleep) in children and adolescents. * Trichotillomania In a meta-analysis of various trials involving fluoxetine (Prozac), fluvoxamine (Luvox), and sertraline (Zoloft) to test their relative efficacies in treating OCD, clomipramine was found to be the most effective. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「clomipramine」の詳細全文を読む スポンサード リンク
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