|
Collagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria such as ''Clostridium''. They are considered a virulence factor, facilitating the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs. Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secreted from the cell. This stops large structures from forming inside the cell itself. In addition to being produced by some bacteria, collagenase can be made by the body as part of its normal immune response. This production is induced by cytokines, which stimulate cells such as fibroblasts and osteoblasts, and can cause indirect tissue damage. ==Therapeutic uses== Collagenases have been approved for medical uses for * treatment of Dupuytren's contracture and Peyronie's disease (Xiaflex). * wound healing〔 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501117/ 〕 (Santyl) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「collagenase」の詳細全文を読む スポンサード リンク
|