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contryphan
The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus conus). The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including
epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation.
==Family members==
Contryphan family members include:
where the sequence abbreviations stand for:
* O = 4-trans-hydroxyproline,
* l = D-leucine, L = L-leucine,
* w = D-tryptophan, W = L-tryptophan,
* γ = gamma-carboxyglutamic acid,
* NH2 = C-terminal amidation
and the remainder of the letters refer to the standard one letter abbreviations for amino acids.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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